Studies have reported an association of reduced testosterone level with AD and dementia.38,39 Moreover, epidemiological and in vivo studies have suggested that LH contributes to cognitive decline and β-amyloid accumulation, which is a pathological AD hallmark.40,41 We did not identify a clinically meaningful hazard on GnRH agonist treatment compared with patients who did not receive ADT. Here, GNRH1 is linked to Alzheimer disease.