Compared with those who did not receive ADT, there was no significant difference in the risk of dementia or AD among patients treated with GnRH agonist or orchiectomy (GnRH agonist: weighted HR, 1.13; 95% CI, 1.00-1.28; orchiectomy: 1.00; 95% CI, 0.74-1.37). The gene discussed is GNRH1; the disease is dementia.