KCNJ8 and cardiac hypertrophy: ,3,8,18 Cardiac hypertrophy is also present in genome-edited “Cantú mice,” in which human disease-associated mutations were introduced into either the endogenous ABCC9 or KCNJ8 genes, despite no apparent alteration of KATP channel properties in the ventricular myocytes of KCNJ8-mutant (Kir6.1wt/VM) mice.19