LAML (acute myeloid leukaemia), LGG (Brain Lower Grade Glioma), ORCA (oral carcinoma), LICA (liver carcinoma), KIRC (Kidney renal clear cell carcinoma), GACA (gastric cancer), BLCA (Bladder Urothelial Carcinoma) cancer from TCGA project showed enrichment of mutations in miRNA regions while GACA and ESAD (oesophageal adenocarcinoma) showed mutational enrichment in CBS regions (Figure S2). This evidence concerns the gene CBS and lip and oral cavity carcinoma.