SMAD4 and colorectal carcinoma: Including 6 classical CRC somatic mutations genes (TP53, APC, KRAS, FBXW7, PIK3CA and SMAD4),5, 6 novel somatic mutations, such as TCF7L2, TET2, TET3 and ERBB3, were also identified, which alluded to possible treatment avenues for CRC.7