APP and Alzheimer disease: Moreover, our data help clarify the interdependence between cholesterol and APP metabolism (Marquer et al, 2011; DelBove et al, 2019) and the controversial association between cholesterol levels and AD (Wood et al, 2014), which we believe may be rooted in the fact that defects in neuronal transmission could be caused by alterations in the distribution of subcellular cholesterol (DelBove et al, 2019) rather than in overall changes in cellular cholesterol concentration.