CD4 and neoplasm: Chlorine e6 and doxorubicin-loaded hollow manganese dioxide nano platform (H-MnO2-PEG/C&D) will alleviate tumor suppression, although checkpoint blocking (PD-L1 blocking) promotes higher TNF-α secretion and improved immune response of CD4 + and CD8 + T cells that chemo-PDT therapy (Yang et al., 2017).