SGLT2 inhibition therefore results in glucosuria, and the ensuing osmotic diuresis may potentially be beneficial particularly for those with T2D and HF.6,9 Whether SGLT2 inhibitors cause significant natriuresis is less clear, but is important in the context of patients with HF who are likely to also be prescribed loop diuretics. Here, SLC5A2 is linked to type 2 diabetes mellitus.