The finding of a significant reduction in serum urate with empagliflozin has been documented previously; however, it is reassuring that we also observed this in patients with HF taking a regular loop diuretic.25 This may again provide evidence to favor use of SGLT2 inhibitors as an add-on therapy in patients with HF with fluid congestion rather than thiazide diuretics or other alternatives. The gene discussed is SLC5A2; the disease is hydrops fetalis.