APOE and diabetes mellitus: These reports suggest that 100% chance to develop Alzheimer in diabetic individuals having a lack of insulin production than those with sufficient insulin production.14 Some studies also show significant association in diabetic patients who lack apolipoprotein E4 (ApoE4) and may lead to diabetes-associated Alzheimer.15,16 So maybe this is one of the markers for the progression risk factor for Alzheimer in patients with diabetes mellitus.