It further demonstrated that DPPI1c acts as a GLP-1 inhibitor by inhibiting DPP-IV enzyme which is further helpful for the treatment of type 2 diabetes mellitus.93 Increase in plasma GLP-1 levels and improved glucose tolerance in diabetic mice was reported after the treatment with DPPI 1c hydrochloride. The gene discussed is GCG; the disease is type 2 diabetes mellitus.