It is shown to increase in vitro insulin signaling and uptake of glucose in the skeletal muscle cells by the action of insulin.88 It has also been observed that WY-14643 tends to ameliorate the memory impairments in mice induced by scopolamine by the activation of PPARα and mediation of brain-derived neurotrophic factor pathway.89 Further, other reported studies such as attenuation of neurodegeneration caused by amyloid β in vitro and prevention of neuroinflammation also points toward the high probability of its effectiveness in type 3 diabetes mellitus.90,91. The gene discussed is INS; the disease is memory impairment.