INS and diabetes mellitus: Low expression of acetylcholine transferase due to suboptimal levels of insulin and desensitization of insulin receptor may reduce the Ach in neurons of diabetic patients resulting in Alzheimer.16,50 Apolipoproteins are key enzymes in lipid metabolism, which deposit the neurotoxin Aβ, and certain isoforms of these apolipoproteins are responsible for the development of Alzheimer.51 Amylin is a first isolated enzyme obtained from amyloid deposits in patients with type 2 diabetes mellitus.