Increased levels of inflammation markers such as fibrinogen, C-reactive protein (CRP), interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), sialic acid, and white cell count are associated with the type 2 diabetes mellitus.48 The Aβ peptide plays a central role in the neuroinflammation hypothesis of Alzheimer, which states that Aβ accumulation results in increased levels of inflammatory molecules (eg, cytokines, chemokines, and complement proteins) produced by chronically activated Glia. The gene discussed is SERPINE1; the disease is diabetes mellitus.