Combining early markers such as MMSE, APOE genotype, and olfactory identification deficit have been shown strong prediction capability for dementia in long‐term cohort studies, however, the prediction models were mainly based on logistic regression analysis, and the performance of the models was not validated using unseen data or cross‐validation (Conti et al., 2013; Devanand et al., 2008, 2015; Liang et al., 2020; Stanciu et al., 2014). The gene discussed is APOE; the disease is dementia.