SIX4 and hypogonadotropic hypogonadism: In panel 1 associated with pituitary and hypogonadotropic hypogonadism, we found that candidate pathogenic variants were present in WDR11, CHD7, WNT5A, GLI, SIX4, OTUD4, CDON, PCSK1, DMXL2, GH1, TACR3, GNAS, SIX4 and LHX4. GLI2 and SIX4 had the same variants distributed in two patients, and GNAS had a stop‐gain mutation (Table 2).