Here, we identified compound heterozygous missense variants MYO7A:p.[Phe456Phe]; p.[Met708Val] and a homozygous variant, p.(Gly163Arg), in two Iranian families with nonsyndromic hearing loss which are affecting the myosin head‐like domain containing residues 1 to 729 of the protein. This evidence concerns the gene MYO7A and hearing loss disorder.