That is, in anti-MPO-associated glomerulonephritis induced by immunizing MPO-deficient mice with murine MPO followed by irradiation and the transplantation of wild-type bone marrow, proteinuria (albuminuria) and hematuria were significantly reduced compared to the controls by both standard steroid/cyclophosphamide treatment and bortezomib treatment [22]. Here, MPO is linked to glomerulonephritis.