SOD1 and amyotrophic lateral sclerosis: A significant number of studies revealed ALS association with SOD1 misfolding and aggregation (Rakhit & Chakrabartty, 2006; Rotunno & Bosco, 2013; Lee & Kim, 2015; Pickles et al., 2016; Pansarasa et al., 2018; Paré et al., 2018).