By multivariate analysis we identified 3 conditions associated with stage IIB or severe COVID-19; history of hypertension [Odds ratio (OR) 2, 95% confidence interval (CI) 1.3–3.2, p = 0.02], baseline lymphopenia (< 0.5 × 109/mL) (OR 1.7, 95% CI 1.1–2.7, p = 0.015) and baseline CRP > 20 mg/dL (OR 2.67, 95% CI 1.6–4.3, p < 0.0001). The gene discussed is CRP; the disease is hypertensive disorder.