In such real-life setting, COVID-19 mortality was mainly driven by advanced age, poor performance status, uncontrolled disease status (not being at least in a partial remission), presence of marrow or immune failure (severe neutropenia, and lymphopenia in the univariate analysis) and having a high baseline and/or COVID-19 induced systemic inflammatory state (identified in the multivariate analysis by high CRP, although high levels of IL-6 and ferritin showed a strong trend in univariate analysis). The gene discussed is IL6; the disease is COVID-19.