SOCS3 and cystic kidney disease: Also, it regulates the expression of genes such as fibrocystin-1 (pkhd1), kinesin-like 12 (kif12), suppressor of cytokine signalling 3 (socs3) and polycystic kidney disease 2 (pkd2), as well as others related to the pathogenesis of the renal cystic disease [14, 15].