FOXP3 and melanoma: Analysis of melanoma treated with ipilimumab showed that improved OS and PFS were associated with baseline values of peripheral blood components, including low absolute neutrophil count, low neutrophil-to-lymphocyte ratio (NLR), low absolute monocyte count, low frequency of myelogenous suppressor cells, high frequency of FoxP3+ Treg cells, high lymphocyte frequency, high eosinophil count; and clinical benefit also associated with the dynamic changes of blood markers during treatment, including decreased FoxP3+Treg concentrations and increased lymphocyte and eosinophil counts [95].