A study detecting TMB (cut-off value at 20 mt/Mb) in 4064 NSCLC patients with the FoundationOne platform containing a 395 gene panel found that compared with TMB-L patients, overall survival (OS) and DCR was significantly improved in TMB-H patients treated with anti-PD-1/L1 drug [11]. This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.