And the predictive value of PD-L1 at different biopsy sites for the benefit of ICIs in NSCLC may vary: higher PD-L1 in lung or distant metastasis specimens was significantly associated with higher response rate, PFS and OS, while PD-L1 in lymph node metastasis biopsy was not associated with either response or survival [72]. Here, CD274 is linked to non-small cell lung carcinoma.