For example, given the effective ORR of 35.5% and a disease control rate (DCR) of 82% in second-line cholangiocarcinoma patients treated with pemigatinib, a new targeted therapy, the recent FDA approval of pemigatinib for the treatment of previously treated patients with locally advanced or metastatic cholangiocarcinoma with fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement, and the comprehensive genomic analysis assay, FoundationOne CDx, developed by Foundation Medicine as a companion diagnostic. This evidence concerns the gene FGFR2 and cholangiocarcinoma.