By sequencing a panel of 32 hotspot driver genes in 5 DLBCL cell lines, only Val cells had a CD79B mutation in the ITAM domain (T212M), and OCI-Ly8 cells had PIM1 mutations in the kinase domain (S188N and L284F), which were both accompanied by mutations in MYC, BCL2, FOXO1, and CREBBP. This evidence concerns the gene CREBBP and diffuse large B-cell lymphoma.