PIM1 and diffuse large B-cell lymphoma: By sequencing a panel of 32 hotspot driver genes in 5 DLBCL cell lines, only Val cells had a CD79B mutation in the ITAM domain (T212M), and OCI-Ly8 cells had PIM1 mutations in the kinase domain (S188N and L284F), which were both accompanied by mutations in MYC, BCL2, FOXO1, and CREBBP.