REN and primary aldosteronism: It is now apparent that at least six genetic variants predispose to a primary aldosteronism/inappropriate aldosterone secretion phenotype (low renin/low aldosterone), best treated with an aldosterone antagonist such as spironolactone or eplerenone, and at least six predispose to a Liddle phenotype (low renin/low aldosterone), best treated with amiloride39.