TIMP1 and systemic sclerosis: They reported lower levels of TIMP-1 in surgically resected inflamed tissue, as compared to C allele carriers.[47] In addition, Indelicato et al reported that TIMP-1 (rs4898) C allele frequency increased in males but not females with systemic sclerosis, as compared to healthy individuals.[48] Along the same lines, Wei et al revealed that C allele carriers of TIMP-1 (rs4898) run a greater risk of developing ankylosing spondylitis disease.[49] Furthermore, it was found that among cirrhotic patients, males with TIMP-1 (372C/T) T allele developed cirrhosis at a younger age.[50]