SIX1 and hepatocellular carcinoma: Since HBP is dependent on the availability of glucose, whether SIX1, a regulator of Warburg effect, could also impact on HBP and subsequent O-GlcNAcylation in HCC still remain unclear and investigating the potential relationship between SIX1, HBP and O-GlcNAcylation will improve our understanding of the function of SIX1 in HCC.