In this study, we reveal a novel pathologic mechanism by which fgl2 expressed by macrophages upregulates the NF-κB and p38-MAPK signaling pathways and NLRP3 inflammasome, resulting in overproduction of proinflammatory cytokines and ROS, which leads to hepatic lipid metabolism disorders and severe liver injury in NASH (Figure 9). This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.