CASP1 and metabolic dysfunction-associated steatohepatitis: In our study, the levels of NLRP3, cleaved caspase-1 (caspase-1 p10), mature IL-1β and IL-18 were all increased in MCD-fed and HFD-fed WT mice compared with controls, while the expression of these proteins was suppressed in fgl2-/-NASH models (Figure 7A).