For instance, GSK-3β overactivation or accumulation might accelerate the depletion of NSC pool and impair AHN through inducing the hyperphosphorylation of tau, a microtubule-associated protein plays pivotal roles in shaping AHN 46-48, since tau hyperphosphorylation has been widely accepted as one of hallmarks of accelerated aging and neurodegenerative diseases 49. The gene discussed is MAPT; the disease is neurodegenerative disease.