By integrating logic-based network modeling and gene expression profiles of cancer cell lines from E2F1-driven bladder tumors and patient cohorts displaying cancer aggressiveness, we identified tumor-type specific receptor signatures associated to EMT, where the combined action of highly expressed E2F1, TGFBR1 and FGFR1 triggers the most invasive phenotype 2,4. The gene discussed is E2F1; the disease is urinary bladder neoplasm.