More than merely sustaining the Warburg phenotype, the establishment of a coherent feedforward loop within the SLC16A1-AS1:E2F1/SLC16A1/MCT1 regulatory axis rewires E2F1 with lipid and mitochondrial metabolism, i.e. two metabolic traits that are emerging as essential factors of tumor progression 100. Here, SLC16A1 is linked to neoplasm.