Next, to assess alterations of PI3K/Akt, FoxO, mTOR, MAPK, and p53 signaling in cancer, we collected data of somatic mutations and DNA copy number variations (amplification, shallow deletion, and deep deletion) from tumor patients (n=9,628) from 27 different cancer types in TCGA through cBioPortal for Cancer Genomics 44. This evidence concerns the gene TP53 and neoplasm.