The mRNA and protein levels of PTEN, AKT1, PIK3CA, and mTOR were significantly upregulated under SAH treatment in GI cancer cells, including gastric cancer cell TMK1, colorectal cancer cell line HCT116, esophageal cancer cell TE-1, pancreatic cancer cell PANC-1, liver cancer cell lines Huh-7 (Figure 7A-B, and S6B) or knocking down the expression levels of METTL3 in TMK1 and HCT116 cells (Figure 7C); Simultaneously, the expression levels were decreased under MA treatment in GI cancer cells (Figure 7A-B). The gene discussed is AKT1; the disease is esophageal cancer.