For example, SCFb-TRCP complex is important for YAP protein polyubiquitination and degradation 29, while our recent study showed that SHARPIN-the LUBAC (linear ubiquitination assembly complex) component, could also facilitate YAP protein K48-linked poly-ubiquitination and degradation in ESCC cells 30. The gene discussed is SHARPIN; the disease is esophageal squamous cell carcinoma.