Interestingly, the genomic sequencing data showed that the deficiency of inhibitory factors of Hippo/YAP pathway, such as AJUBA and FATs mutations, or YAP gene amplification accounted for 48% of ESCC samples, indicating that dys-regulation of Hippo signaling could play critical role in ESCC progression 5. Here, C10orf90 is linked to esophageal squamous cell carcinoma.