VEGFA and neoplasm: In turn, these molecules increase immunosuppressant cytokines such as interleukin (IL): IL-4 and IL-10, TGF-β (transforming growth factor-beta) and vascular endothelial growth factor (VEGF); as well as pro-inflammatory cytokines, such as IL-6 and IL-10, which promote tumour angiogenesis and facilitate the development of metastases [4].