A previous study has demonstrated that HD (100 mg/kg) ameliorates liver fibrosis and decreases the levels of ALT, AST, ALP as well as hepatic MDA content and iNOS gene expression, α-smooth muscle actin (α-SMA) and caspase-3 in dimethylnitrosamine (DMN)-induced rat model [59]. The gene discussed is CASP3; the disease is Hepatic fibrosis.