Microarray analysis from Ohnishi et al. indicated that NOB specifically upregulated the expression of a set of genes involved in the progression of HCC growth, including cytokine-inducible SH2-containing protein (CISH), basigin (BSG) and protein phosphatase 2A 48 kDa regulatory subunit (PR48). This evidence concerns the gene CISH and hepatocellular carcinoma.