A further study reported that TN (5 μM) protected against t-BuOOH-induced oxidative stress and liver injury, as indicated by increased GSH, decreased levels of ROS and LDH and the activation of anti-oxidant pathways, HO-1 and NAD(P)H quinone oxidoreductase 1 (NQO1), which was dependent on Nrf2/ARE pathway activation [128]. This evidence concerns the gene HMOX1 and injury.