Emerging evidence indicated that HD (0.08% in diet) improved hypercholesterolemia and fatty liver injury by inhibiting both the synthesis and absorption of cholesterol, and regulating the mRNA expression of retinol-binding protein (RBP), cutaneous fatty acid-binding protein (C-FABP), and heart fatty acid-binding protein(H-FABP) [50]. The gene discussed is FABP3; the disease is familial hypercholesterolemia.