P2RX7 and alkaline phosphatase measurement: Our previous studies also proved that emodin alleviated AP via miRNA-30a-5p/HtrA serine peptidase 1/transforming growth factor-β (HTRA1/TGF-β) and purinergic receptor P2X, ligand-gated ion channel, 7/NLRP3 (P2X7/NLRP3) inflammatory signaling [50, 51].