Besides, these patients had smaller tumor size (4.0 vs 8.7 and 8.8 cm, p<0.001), lower serum level of AFP (373.2 vs 1992.6 and 3082.2 ng/mL, p=0.028); and more of them had experienced surgical resection for HCC before ICI treatment (62.9% vs 21.1% and 50.0%, p=0.013). The gene discussed is AFP; the disease is neoplasm.