HPGDS and plasma cell myeloma: Interestingly, myeloma cells reacted to the higher ROS production inducing a concomitant activation of antioxidant-related genes such as glutathione S-transferase (GST; FC over control: 25.4 ± 1.7), superoxide dismutase 2 (SOD2; FC over control: 2.45 ± 0.2) and heme oxygenase 1 (HMOX-1; FC over control: 76.9 ± 6.5) as soon as 0.5 h after starting FAC treatment (Fig. 1G–I).