At 2 weeks after TAC, the levels of ANP and BNP were significantly higher in heart tissue of Sesn2 KO and Y-Sesn2 KO + AAV9-scram mice than in heart tissue of WT mice and Y-Sesn2 KO + AAV9-Sesn2 mice. The gene discussed is SESN2; the disease is persistent truncus arteriosus.