PPARGC1A and persistent truncus arteriosus: Immunoblotting results suggested that the expression levels of mitochondrial synthesis-associated proteins (PGC1α, ERRα, PPARα, and CD36) were reduced in young WT, aged WT, and Y-Sesn2 KO mice after TAC surgery; these reductions were greatest in aged WT and Y-Sesn2 KO mice (Fig. 4B and C).