Abnormal expression of RPS6 or phosphorylated-RPS6 has been detected in vulvar squamous cell carcinoma [10], cervical cancer [11], oral squamous cell carcinoma [12], non-small cell lung cancer [13], renal cell carcinoma [14], esophageal squamous cell carcinoma [15]. The gene discussed is RPS6; the disease is esophageal squamous cell carcinoma.