Whilst the selective depletion of Mtb-specific CD4+ T cells has been shown in subjects in the acute phase of HIV infection, our study on latent TB subjects with chronic HIV infection show no evidence for higher viral burden in Mtb-specific cells although, we too report selective loss of Mtb-specific CD4+ T cells compared with cells of other specificities, consistent with a chronic SIV-TB coinfection macaque model (Bucsan et al., 2019). The gene discussed is CD4; the disease is tuberculosis.