Th1 cytokine (IFNγ, TNFα, IL12)-deficient mice succumb to Mtb infection due to high bacterial burden, whereas humans undergoing treatment with TNFα-blocking antibodies or having mutations in genes encoding IFNγ, IL-12 or its receptors are susceptible to TB (O’Garra et al., 2013). This evidence concerns the gene TNF and tuberculosis.