BRCA1 and ovarian cancer: In addition to their role in DNA damage repair, BRCA1 is involved in more functions than BRCA2, such as in healthy embryonic development and onset of breast and ovarian cancer [17], centrosome replication [18], regulation of spindle pole synthesis [19], heterochromatin-satellite RNA expression [20], mesenchymal metabolite synthesis [21], splicing [22], brain size [23], and transcriptional co-activation [24].