PGR and breast cancer: The Western Consortium of Investigators of Modifiers of BRCA1/2: the CIMBA reports on the pathological findings of BRCA1/2 breast cancer as follows [71, 72]: BRCA1-related breast cancer has the following features: (1) histopathological image of medullary carcinoma, which develops in a globular manner in peripheral tissues, (2) high histological nuclear grade, (3) a high proportion of negative for the expression of both estrogen and progesterone receptors and HER2 overexpression.