CEBPZ and acute myeloid leukemia: They had a lower frequency of a normal karyotype (P < 0.001) and were more likely to have a core binding factor AML (CBF-AML, P < 0.001) but also to harbor adverse-risk genetics, i.e. del(5)/del(5q) (P = 0.001), del(7)/del(7q) (P = 0.001), a monosomal karyotype (P = 0.02) [26], a complex karyotype (P = 0.02) [1], as well as worse risk according to ELN2017 classification (P < 0.001, Table 1).