High MN1/ABL1 copy numbers also associated with a lower frequency of a normal karyotype (P < 0.001) and a higher frequency of CBF-AML (P = 0.001) but also a higher frequency of adverse risk genetics as del(7)/del(7q) (P = 0.001), del(5)/del(5q) (P = 0.01), by trend monosomal karyotype (P = 0.09) and worse risk according to ELN2017 classification (P < 0.001, Table 1). This evidence concerns the gene CEBPZ and acute myeloid leukemia.