Recently, miR-488-3p has been reported to be sponged by circ_CCDC66 in Hirschsprung’s disease [30], circ_0020123 in non-small cell lung cancer [31], and lncRNA PVT1 in glioma [32] etc. Therefore, it can be speculated that miR-488-3p function as regulatory hub in the progression of these diseases. Here, PVT1 is linked to Hirschsprung disease.