Evidence for GSDMD-mediated pyroptosis in human macrophages/microglia in vitro and in MS patient white matter was reported previously [9]; likewise, GSDMD immunoreactivity and pyroptosis have been observed in myeloid-lineage cells in the murine CNS during experimental autoimmune encephalomyelitis (EAE) [9, 23]. The gene discussed is GSDMD; the disease is myeloid sarcoma.