In MS lesions, 42.7% of macrophages/microglia were immunopositive for both total and cleaved GSDMD, while a further 21.7% were positive for total but not cleaved GSDMD; by contrast, over 83.3% of macrophages/microglia in non-MS white matter were double-immunonegative for either total or cleaved GSDMD (Fig. 1(C)). Here, GSDMD is linked to myeloid sarcoma.