Within a proinflammatory tumor microenvironment an activation-induced IFN-γ signature promotes the generation of MHC-II complexes [75] and LAG3 recognition of stable peptide-MHC-II complexes is critical for activity [76], making LAG3 a surrogate biomarker of active inflammation in the tumor microenvironment. The gene discussed is LAG3; the disease is neoplasm.