In line with our previous results demonstrating significant correlations between LAG3 mRNA expression and lymphocyte score and inverse correlations between LAG3 promoter methylation and lymphocyte score in whole tumor tissue (Table 1), isolated PBMCs showed pronounced LAG3 hypomethylation in the CpG sites three to seven and 11, all of them located in the promoter region (Fig. 4). Here, LAG3 is linked to neoplasm.