Regarding the above mentioned complex relationship between FKBP5, stress, aging, and inflammation, there is another interesting aspect: A previous review suggests that perfusion deficits in the elderly might trigger microglial activation and subsequent neuroinflammation which in turn plays a central role in the pathophysiology of late-life depression (Popa-Wagner et al. 2014). This evidence concerns the gene FKBP5 and depressive disorder.