NFKB1 and coronary artery disorder: To date, there is only few evidence on a possible association of CHD or CHD risk factors with FKBP5. As CHD is robustly linked to peripheral inflammation (Kaptoge et al. 2014), and FKBP5 promotes inflammation by activating the central immune regulator NF-κB (Erlejman et al. 2014), it is plausible to assume that FKBP5 shapes cardiovaskular risk via this pathway.