CLCN5 and Dent disease: Intriguingly, although LMWP is considered the clue to a diagnosis of Dent disease, two males with CLCN5 mutations reportedly had no LMWP at the time of their diagnosis, but they did have other symptoms of Dent disease, such as hypercalciuria (Scheinman et al. 2000; Anglani et al. 2015).