Other studies focused on the secondary and tertiary structure of the ClC-5 protein, looking at changes in CBS domain 2 (CBS2) (Carr et al. 2003), or the N-glycosylation site (Schmieder et al. 2007), more to see how the protein works than to clarify its role in Dent disease. The gene discussed is CLCN5; the disease is Dent disease.