In addition to showing up‐regulation of previously reported inflammasome components and their effector molecules including NLRP3, ASC, IL‐1β and IL‐18,20 further analysis of NLR signalling pathways using Pathview and Morpheus also showed less well‐characterized genes, such as elevated GSDMD, CTSB, p22phox and TRX1 (TXN1), and reduced AIM2, p202 and TXNIP in MCT‐induced PAH (Figure S2; Figure 4C). Here, AIM2 is linked to pulmonary arterial hypertension.