Of this inflammatory and immune profiling, it is noteworthy that several inflammatory factors including CCL2,30 SELP,31 SPP1,32 IL17,33 IL1B,2 IL12A,2 ADA34 and PF435 have already been demonstrated to be associated with pulmonary vascular remodelling/pulmonary hypertension. The gene discussed is SPP1; the disease is pulmonary arterial hypertension.