Binary logistic regression analysis showed that one unit increase in SAA, IL‐6, and NLR, the risk of nonsevere patients with COVID‐19 becoming severe patients increased significantly (SAA: OR = 4.212, P = .039; IL‐6: OR = 1.281, P = .029; NLR: OR = 5.180, P = .033). This evidence concerns the gene IL6 and COVID-19.