PRKCG and aceruloplasminemia: In a transgenic mouse model in which the human S361G point mutation associated with SCA14 is expressed specifically in cerebellar Purkinje cells (PKCγ(S361G)-mice) [8], the mice develop mild symptoms of cerebellar ataxia and show decreased dendritic development of Purkinje cells throughout the cerebellum [9], especially in lobule VII [8].