SYT5 and neuroblastoma: In order to further confirm both, expression of Syt5 in SiMa neuroblastoma cells and interactions of α-HPy and α-CJe with Syt5 in these cells, a-gene specific knockdown of the Syt5 mRNA was performed by transfecting these cells with a commercial Syt5 shRNA expression vector (Supplementary Fig. 5).