Based on the unusual morphology for benign fibrous histiocytoma, the ALK expression by IHC and the fact that “epithelioid fibrous histiocytoma (EFH)” commonly demonstrate ALK fusions [41–43], NGS testing was performed and revealed IRF2BP2-NTRK1 fusion (Fig. 3). The gene discussed is ALK; the disease is benign fibrous histiocytoma.