CEBPB and Alzheimer disease: As expected, the C/EBPβ/δ-secretase axis is activated in an age-dependent manner in different brain regions of the 3×Tg AD mouse model, elevating δ-secretase-truncated APP and Tau proteolytic fragments and promoting senile plaques and NFT formation in the brain, associated with gradual neuronal loss and chronic neuroinflammation.