As expected, the C/EBPβ/δ-secretase axis is activated in an age-dependent manner in different brain regions of the 3×Tg AD mouse model, elevating δ-secretase-truncated APP and Tau proteolytic fragments and promoting senile plaques and NFT formation in the brain, associated with gradual neuronal loss and chronic neuroinflammation. This evidence concerns the gene MAPT and Alzheimer disease.