CD4 and cancer: Our final signature matrix consisted of 2215 differentially methylated CpGs distinguishing between 12 broad cell types: Tregs, CD4+ T-cells (CD4T), CD8+ T-cells (CD8T), B-cells (B-cell), natural killer (NK) cells, eosinophils, neutrophils, monocytes, endothelial cells, glial cells, neurons, and cancer.