TGM4 and neoplasm: Separate xenografts generated from orthotopic injections of TGP+ or TGP− cells revealed a reduced tumor burden (Fig. 3e, Supplementary Fig. 20a–b) and enhanced survival (Fig. 3f) in TGP+ xenografts compared with TGP−, with some TGP+ cells reverting back to TGP− cells as observed by immunostaining for GFP positivity in these xenografts (Fig. 3g).