More importantly, only 1/38 tumor specimen expressed PD-L2 only without PD-L1 but 14/38 specimens expressed PD-L1 without PD-L2 and 7/38 specimens expressed both PD-L1 and PD-L2, the remaining 16/38 specimens were PD-L1 and PD-L2 negative. This evidence concerns the gene CD274 and neoplasm.