PNPLA3 and metabolic dysfunction-associated steatotic liver disease: The mechanism for Mboat7-induced hepatic TG accumulation is distinct from the other two genetic variants associated with NAFLD in humans, TM6sf2 and PNPLA3. TM6sf2 is involved in the lipidation of apolipoprotein B for the production of TG-rich lipoproteins (26, 31).