In fact, APOE ε4-mediated Aβ pathology likely depends on LRP1, as LRP1 deficiency in neurons blocks the APOE ε4-mediated exacerbation of amyloid plaque burden in APP/PS1 (PSEN1) double-transgenic mice (Box 1) (Tachibana et al., 2019). Here, APOE is linked to amyloidosis.